First came the Calvin and Hobbes reinterpretation featuring Calvin on Ritalin, which made many readers sad. Then came the comic featuring Calvin shrugging off Ritalin’s effects.
I’ve also pointed you to an essay that postulates that Fight Club is really just Calvin and Hobbes set later in Calvin’s life:
I now present Dalvin and Holly, which features a character named “Dalvin” and his imaginary friend:
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Missing callout in last frame:
“Stop cock-blocking me, Dad!”
So, are there more of these?